Niranjan, A., Tewari, S.K., and Lehry, A., 2010, Biological Activities of Kalmegh (A. Mycek, M.J., Harvey, R.A., Champe, P.C., and Fisher, B.D., 2001, Farmakologi Ulasan Bergambar Edisi 2, 1995, Cetakan I. Mayur, B., Sandesh, S., Shruti, S., and Sung-Yum, S., 2010, Antioxidant and О±-glucosidase inhibitory properties of Carpesium abrotanoides L., Journal of Medicinal Plants Research, 4 (15): 1547-1553 Katzung, B.G., 2002, Farmakologi Dasar dan Klinik, diterjemahan dari Bahasa Inggris oleh Bagian Farmakologi Fakultas Kedokteran Universitas Airlangga, Salemba Medika, pp: 349, 694-709 pp:16, 24, 36-46Дepkes RI, 2009, Farmakope Herbal Indonesia, Departemen Kesehatan RI, Jakarta and Lin, B.F., 2010, Isolation and Identification of Bioactive Compounds in Andrographis paniculata (Chuanxinlian), Chinese Medicine Journal, 5: 1-15Дep Kes RI, 2005, Pharmaceutical Care Untuk Penyakit Diabetes Mellitus, Dep Kes RI, Jakarta. Technol., 8: 46-54ДЄulia, N., 2008, Penetapan Kadar Andrografolid dan Kurkumin dalam Ekstrak Campuran Herba Sambiloto dan Rimpang Kunyit dengan Metode KLT-densitometri, Universitas Airlangga, Skripsi, SurabayaД¬hao, W.W. 2007, Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension, Inn. 2008, In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide, Act. Subramanian, R., Asmawi, M.Z., and Sadikun, A. 2006, О±-Amylase inhibitory activity of some Malaysian plants used to treat diabetes with particular reference to Phyllanthus amarus. ДЄli, H., Houghton, P.J., and Soumyanath, A. Inhibition of О±-amylase activity is evidence of one mechanism of andrographolide in reducing carbohydrate metabolism that can affect blood glucose levels and indicates that andrographolide is a potential alternative medicine in addressing diabetes mellitus. Andrographolide isolates showed fairly good activity in inhibiting О±-amylase ( IC 50 = 1.49 mg/mL) and weak in inhibiting О±-glucosidase (IC 50 = 38,86 mg/mL). Research had been conducted in an effort to develop an alternative treatment of diabetes mellitus by testing the ability of isolates of andrographolide in inhibiting О±-amylase activity and О±-glucosidase in vitro. The absorption process is catalyzed by О±- 1 ,4 - glycoside breaking bond enzyme, namely О± - amylase and О± -1 ,6 - glycoside breaking bond enzyme, namely О± вЂ“ glucosidase. Carbohydrates are metabolized in the gastrointestinal tract into simple glucose and absorbed into the bloodstream and affected blood glucose levels.

Disorders of carbohydrate metabolism can lead to diabetes mellitus.

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